The mission of the Medicinal Chemistry Core at Dana-Farber Cancer Institute is to collaborate with Institute researchers to deliver high quality small molecule probes and lead therapeutics for cancer models being studied by the collaborating scientist. These collaborations typically initiate with the medicinal chemistry team assisting with prioritization and validation of HTS hits, and progress through lead optimization to yield compounds with excellent potency and drug-like properties. The Medicinal Chemistry Core is comprised of experienced medicinal and synthetic chemists with lab space located on Dana-Farber’s Harbor Campus.
If you are interested in working with the medicinal chemistry core on a probe/drug discovery project please initiate the process by filling out a services request form on the 'Request Services' tab. Pick the most appropriate of two forms, either ''Analysis of HTS actives, hit validation and/or target identification" or "Probe/drug discovery collaboration" to help us learn a little about your project. We will then contact you to set up a meeting to discuss in more detail the goals of the project and how we can help meet them.
We are also happy to assist researchers in obtaining reference compounds needed in their research. To initiate the process, fill out Reference Compounds Project Request on the 'Request Services' tab.
Purchase Orders are to be made out to:
Dana Farber Cancer Institute
General Accounting, BP-425
450 Brookline Avenue
Boston, MA 02215-5450
Note to Partners, Harvard, Boston Children’s and Tufts researchers:
If you are using a PO from an institution other than one under which you signed in, you must stop and contact the DFCI iLab staff at firstname.lastname@example.org
Nathanael Gray, PhD - Core Director
Sara Buhrlage, PhD – Research Scientist
Phone: (617) 582-7256
Hwan Geun, PhD – Research Scientist
Dana-Farber Harbor Campus, 27 Drydock Avenue, Boston, MA 02210
628A Seeley Mudd, 250 Longwood Avenue
DD430, 27 Drydock Avenue, Boston, MA 02210