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Core - The Medicinal Chemistry, DFCI

Overview of The Medicinal Chemistry Core

 

The mission of the Medicinal Chemistry Core at Dana-Farber Cancer Institute is to collaborate with Institute researchers to deliver high quality small molecule probes and lead therapeutics for cancer models being studied by the collaborating scientist.  These collaborations typically initiate with the medicinal chemistry team assisting with prioritization and validation of HTS hits, and progress through lead optimization to yield compounds with excellent potency and drug-like properties.  The Medicinal Chemistry Core is comprised of experienced medicinal and synthetic chemists with lab space located on Dana-Farber’s Harbor Campus.

 

If you are interested in working with the medicinal chemistry core on a probe/drug discovery project please initiate the process by filling out a services request form on the 'Request Services' tab.  Pick the most appropriate of two forms, either ''Analysis of HTS actives, hit validation and/or target identification" or "Probe/drug discovery collaboration"  to help us learn a little about your project.  We will then contact you to set up a meeting to discuss in more detail the goals of the project and how we can help meet them.    

 

We are also happy to assist researchers in obtaining reference compounds needed in their research.  To initiate the process, fill out Reference Compounds Project Request on the 'Request Services' tab.

 

Information for Users External to DFCI

Purchase Orders are to be made out to:

Dana Farber Cancer Institute

General Accounting, BP-425

450 Brookline Avenue

Boston, MA 02215-5450

 

Note to Partners, Harvard, Boston Children’s and Tufts researchers:

  • Partners Health Care (includes MGH, BWH, McLean, Spaulding, etc): choose vendor 0000008573
  • Harvard (includes HMS,Dental, Wyss, HSPH, etc.): choose vendor site: 01_PRIMARY
  • Tufts University: choose Supplier 0000000655
  • Boston Children’s Hospital: choose vendor 0000001886

 

 If you are using a PO from an institution other than one under which you signed in, you must stop and contact the DFCI iLab staff at sc_billing@dfci.harvard.edu

Leadership

 

Nathanael Gray, PhD - Core Director

Phone:

Email: nathanael_gray@dfci.harvard.edu

 

Sara Buhrlage, PhD – Research Scientist

Phone: (617) 582-7256

Email: saraj_buhrlage@dfci.harvard.edu

 

Hwan Geun, PhD – Research Scientist

Phone:

Email: hwan_choi@dfci.harvard.edu

 

 

Location and hours of operation

Hours Location
Monday-Friday 9-5

Dana-Farber Harbor Campus, 27 Drydock Avenue, Boston, MA 02210

Links and Resources

  1. DFCI Medicinal Chemistry Core Website

Contacts

Name Role Phone Email Location
Nathanael Gray
Director
 

 
nathanael_gray@dfci.harvard.edu
 
628A Seeley Mudd, 250 Longwood Avenue
 
Sara Buhrlage
Research Scientist
 

 
saraj_buhrlage@dfci.harvard.edu
 
DD430, 27 Drydock Avenue, Boston, MA 02210